Biodegradable Polymeric Nanoparticles Containing an Immune Checkpoint Inhibitor (aPDL1) to Locally Induce Immune Responses in the Central Nervous System

نویسندگان

چکیده

Immunotherapy is an efficient approach to clinical oncology. However, the immune privilege of central nervous system (CNS) limits application immunotherapeutic strategies for brain cancers, especially glioblastoma (GBM). Tumor resistance checkpoint inhibitors a further challenge in immunotherapies. To overcome immunological tolerance tumors, novel multifunctional nanoparticle (NP) highly synergetic immunotherapy reported. The NP contains anti-PDL1 antibody (aPDL1), upconverting NPs, and photosensitizer 5-ALA; surface conjugated with B1R kinin ligand facilitate transport across blood-tumor-barrier. Upon irradiation 980 nm laser, 5-ALA transformed into protoporphyrin IX, generating reactive oxygen species. Photodynamic therapy (PDT) promotes intratumoral infiltration cytotoxic T lymphocytes sensitizes tumors PDL1 blockade therapy. It demonstrated that combining PDT aPDL1 can effectively suppress GBM growth mouse models. proposed NPs provide effective strategy boosting anti-GBM photoimmunotherapy.

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ژورنال

عنوان ژورنال: Advanced Functional Materials

سال: 2021

ISSN: ['1616-301X', '1616-3028']

DOI: https://doi.org/10.1002/adfm.202102274